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最終更新日：2024/02/29
品川 明穂
シナガワ アキホ
(Akiho Shinagawa)
論文
- タイトル
- タイトル（英）
- Changes in homocysteine and non-mercaptoalbumin levels after acute exercise: a crossover study.
- 参照URL
- https://researchmap.jp/a.shinagawa/published_papers/42226697
- 著者
- 著者（英）
- Akiho Shinagawa,Tomoki Yamazaki,Ayako Minematsu,Naho Serizawa,Yuri Hosoi,Yusuke Ninomiya,Yuichi Miyakoshi,Tomohiro Yano,Masako Ota
- 担当区分
- 筆頭著者
- 概要
- 概要（英）
- BACKGROUND: Acute exercise is one factor that increases blood homocysteine levels, and elevated homocysteine levels cause oxidative stress. Albumin, which is abundant in blood, is an antioxidant, and the redox state of albumin is used as an index of oxidative stress in blood. This study aimed to assess the effect of acute exercise on plasma homocysteine levels and the blood non-mercaptoalbumin/mercaptoalbumin ratio as an oxidative stress marker. METHODS: This study used a crossover design with exercise and control conditions. Under exercise conditions, a bicycle ergometer was used to perform 40 min of transient constant-load exercise at 65% heart rate reserve. Under control conditions, participants rested for 40 min. Blood was collected before, 30 min after, and 90 min after exercise, and at the same time points under control conditions. Samples were analyzed for the homocysteine concentration and non-mercaptoalbumin/mercaptoalbumin ratio. RESULTS: The results revealed that a 65% heart rate reserve and 40 min of acute exercise increased plasma homocysteine concentration and non-mercaptoalbumin ratio. In the intra-condition comparison, the plasma Hcy concentration was significantly increased at Post 30 min (+ 0.83 ± 0.70 µmol/L, P = 0.003) compared with that at Pre in the exercise condition. Furthermore, 90 min after exercise, the blood non-mercaptoalbumin ratio was significantly increased (+ 0.35 ± 0.71%, P = 0.030) compared to Pre. CONCLUSION: These results indicate that the plasma Hcy concentration first increased, and then the non-mercaptoalbumin/mercaptoalbumin ratio increased as the elevated state was maintained. This study revealed that 65% heart rate reserve, 40 min of acute exercise increased plasma Hcy concentration and non-mercaptoalbumin ratio.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- BMC sports science, medicine & rehabilitation
- 巻
- 15
- 号
- 1
- 開始ページ
- 59
- 終了ページ
- 59
- 出版年月
- 2023年4月17日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1186/s13102-023-00656-w
- 共同研究・競争的資金等の研究課題