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最終更新日：2024/10/20
原村 未来
ハラムラ ミキ
(Miki Haramura)
論文
- タイトル
- タイトル（英）
- Effects of oral cystine and glutamine on exercise-induced changes in gastrointestinal permeability and damage makers in young men.
- 参照URL
- https://researchmap.jp/miki.haramura/published_papers/36298517
- 著者
- 著者（英）
- Yusei Tataka,Miki Haramura,Yuka Hamada,Miho Ono,Sakiko Toyoda,Toshiyuki Yamada,Ayano Hiratsu,Katsuhiko Suzuki,Masashi Miyashita
- 担当区分
- 概要
- 概要（英）
- Abstract Purpose Although acute prolonged strenuous exercise has been shown to increase markers of gastrointestinal permeability and damage, little is known regarding the efficacy of nutritional supplement interventions on the attenuation of exercise-induced gastrointestinal syndrome. This study addressed the effects of oral amino acid supplementation on markers of gastrointestinal permeability and damage in response to exercise. Methods Sixteen active men aged 22.7 ± 2.6 years (mean ± standard deviation) completed placebo or cystine and glutamine supplementation trials in random order. Participants received either a placebo or cystine and glutamine supplements, three times a day for 5 days, separated by a 2-week washout period. On day 6, participants took their designated supplements 30 min before running at a speed corresponding to 75% of maximal oxygen uptake for 1 h, followed by a 4-h rest period. Blood samples were collected pre-exercise, immediately post-exercise, 30 min post-exercise, and 1, 2 and 4 h post-exercise on day 6. The plasma lactulose to mannitol ratio (L:M) and plasma intestinal fatty acid-binding protein (I-FABP) were used as markers of gastrointestinal permeability and damage, respectively. Results Plasma L:M (linear mixed model, coefficient ± standard error: − 0.011 ± 0.004, P = 0.0090) and changes (i.e., from pre-exercise) in plasma I-FABP (linear mixed model, − 195.3 ± 65.7 coefficient ± standard error (pg/mL), P = 0.0035) were lower in the cystine and glutamine supplementation trial than in the placebo trial. Conclusion Oral cystine and glutamine supplementation attenuated the markers of gastrointestinal permeability and damage after 1 h of strenuous running in young men. Trial registration number UMIN000026008. Date of registration 13 December 2018.
- 出版者・発行元
- 出版者・発行元（英）
- Springer Science and Business Media LLC
- 誌名
- 誌名（英）
- European Journal of Nutrition
- 巻
- 61
- 号
- 5
- 開始ページ
- 2331
- 終了ページ
- 2339
- 出版年月
- 2022年8月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 1436-6207
- DOI URL
- https://doi.org/10.1007/s00394-022-02806-1
- 共同研究・競争的資金等の研究課題