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最終更新日：2024/02/01
大岩 奈青
オオイワ ナオ
(Nao Ohiwa)
論文
- タイトル
- タイトル（英）
- Lack of association between genotype score and sprint/power performance in the Japanese population
- 参照URL
- https://researchmap.jp/naoohiwa/published_papers/31761887
- 著者
- 著者（英）
- Eri Miyamoto-Mikami,Haruka Murakami,Hiroyasu Tsuchie,Hideyuki Takahashi,Nao Ohiwa,Motohiko Miyachi,Takashi Kawahara,Noriyuki Fuku
- 担当区分
- 概要
- 概要（英）
- © 2016 Sports Medicine Australia Objectives This study aimed to examine the association between a total genotype score (TGS) based on previously published genetic polymorphism candidates and differences in sprint/power performance. Design Case–control association study. Methods We analysed 21 polymorphisms, which have previously been associated with sprint/power performance and related phenotypes, in 211 Japanese sprint/power track and field athletes (77 regional, 72 national, and 62 international athletes) and 649 Japanese controls using the TaqMan SNP genotyping assay. We calculated the TGS (maximum value of 100 for the theoretically optimal polygenic score) for the 21 polymorphisms. Results All groups exhibited similar TGSs (control: 55.9 ± 7.2, regional: 55.1 ± 7.1, national: 56.1 ± 7.4, and international: 56.0 ± 7.8, p = 0.827 by one-way analysis of variance). Nine of the 21 polymorphisms had the same direction of effect (odds ratio >1.0) as in previous studies, while 12 had the opposite direction of effect (odds ratio <1.0). Three polymorphisms (rs699 in AGT, rs41274853 in CNTFR, and rs7832552 in TRHR), which had the same direction of effect as in previous studies, were associated with international sprint/power athlete status (p < 0.05). However, after multiple testing corrections, the statistical significance of these polymorphisms was not retained. Conclusions These results suggest that TGSs based on the 21 previously published sprint/power performance-associated polymorphisms did not influence the sprint/power athlete status of Japanese track and field athletes. However, our results maintain the possibility that three of these polymorphisms might be associated with sprint/power performance.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Journal of Science and Medicine in Sport
- 巻
- 20
- 号
- 1
- 開始ページ
- 98
- 終了ページ
- 103
- 出版年月
- 2017年1月1日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 1440-2440
- DOI URL
- https://doi.org/10.1016/j.jsams.2016.06.005
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