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最終更新日：2025/06/29
高橋 祐美子
(Yumiko TAKAHASHI)
論文
- タイトル
- タイトル（英）
- Post-exercise ketone monoester administration concomitant with glucose stimulates glycogen repletion in soleus muscle in mice.
- 参照URL
- https://researchmap.jp/yumikotakahashi/published_papers/50504363
- 著者
- 著者（英）
- Yumiko Takahashi,Tatsuya Matsumoto,Wenxin Wang,Takeru Inaba,Shin Terada,Hideo Hatta
- 担当区分
- 概要
- 概要（英）
- Although our group has demonstrated that the administration of β-hydroxybutyrate, a major type of ketone body, stimulated post-exercise glycogen repletion in isolated skeletal muscle, investigations of the effects of ketone supplementation on post-exercise muscle glycogen repletion in vivo have obtained conflicting results. Here, we investigated the effects of an oral intake of the ketone monoester ((R)-3-hydroxybutyl (R)-3-hydroxybutyrate) on post-exercise glycogen repletion in mouse skeletal muscles. Ten-week-old male Institute of Cancer Research mice ran on a treadmill at 25 m/min speed for 60 min. Immediately after the exercise, the mice were orally administered a solution containing 1.0 g/kg body weight (BW) of glucose and 2.0 g/kg BW of ketone monoester (KE solution) or a solution containing glucose and 1.11 g/kg BW of triolein for the adjustment of total calories to match the KE solution's (Con solution). The KE-treated group showed significantly lower post-administration blood glucose concentrations and higher plasma insulin concentrations compared to those of the Con-treated group. The KE-treated group showed a 42.1% higher glycogen concentration in soleus muscle (slow-twitch fiber-dominant) at 60 min post-administration compared to that of Con group. There was no significant between-group difference in the glycogen concentration in the plantaris muscle (fast-twitch fiber-dominant). The KE-treated group's soleus muscle also showed significantly lower phosphorylation levels of AMP-activated kinase Thr172 at 30 min post-exercise compared to the level immediately post-exercise. These results demonstrated that a post-exercise administration of ketone monoester enhanced glycogen repletion, particularly in slow-twitch fiber-dominant muscle.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- American journal of physiology. Cell physiology
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2025年6月25日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1152/ajpcell.00311.2025
- 共同研究・競争的資金等の研究課題