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最終更新日:2024/04/26

田中 喜晃

タナカ ヨシアキ (Yoshiaki Tanaka)
論文
タイトル
タイトル(英)
Metabolic flexibility during sleep.
参照URL
https://researchmap.jp/yoshiaki-tanaka/published_papers/46302105
著者
著者(英)
Zhang S,Tanaka Y,Asuka Ishihara,Akiko Uchizawa,Insung PARK,Iwayama K,Ogata H,Yajima K,Omi N,Satoh M,Yanagisawa M,Hiroyuki Sagayama,徳山 薫平
担当区分
概要
概要(英)
Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.
出版者・発行元
出版者・発行元(英)
誌名
誌名(英)
Scientific reports
開始ページ
終了ページ
出版年月
2021年9月8日
査読の有無
招待の有無
掲載種別
研究論文(学術雑誌)
ISSN
DOI URL
https://doi.org/10.1038/s41598-021-97301-8
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