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最終更新日:2024/04/26
田中 喜晃
タナカ ヨシアキ
(Yoshiaki Tanaka)
論文
- タイトル
- タイトル(英)
- Metabolic flexibility during sleep.
- 参照URL
- https://researchmap.jp/yoshiaki-tanaka/published_papers/46302105
- 著者
- 著者(英)
- Zhang S,Tanaka Y,Asuka Ishihara,Akiko Uchizawa,Insung PARK,Iwayama K,Ogata H,Yajima K,Omi N,Satoh M,Yanagisawa M,Hiroyuki Sagayama,徳山 薫平
- 担当区分
- 概要
- 概要(英)
- Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.
- 出版者・発行元
- 出版者・発行元(英)
- 誌名
- 誌名(英)
- Scientific reports
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2021年9月8日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文(学術雑誌)
- ISSN
- DOI URL
- https://doi.org/10.1038/s41598-021-97301-8
- 共同研究・競争的資金等の研究課題