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最終更新日：2024/03/31
石橋 彩
イシバシ アヤ
(Aya Ishibashi)
論文
- タイトル
- タイトル（英）
- Influence of an energy deficient and low carbohydrate acute dietary manipulation on iron regulation in young females.
- 参照URL
- https://researchmap.jp/aya_1484/published_papers/39596992
- 著者
- 著者（英）
- Nanako Hayashi,Aya Ishibashi,Ayame Iwata,Haruka Yatsutani,Claire Badenhorst,Kazushige Goto
- 担当区分
- 概要
- 概要（英）
- Hepcidin is a liver-derived hormone that regulates iron metabolism. Recent studies suggest that an energy-deficient diet or low carbohydrate (CHO) availability may increase hepcidin in the absence of inflammation. The purpose of the present study was to examine the impact of either an energy-deficient diet or an ED diet with low CHO intake during three consecutive days on hepcidin responses, hematological variables, and energy metabolism in young Japanese women. Twenty-two young females were divided into two different groups, either an energy-deficient with low CHO intake group (ED + LCHO; 2.0 ± 0.3 g/kg/day CHO, 39%CHO, 1123 kcal/day) or an energy deficient with moderate CHO intake group (ED; 3.4 ± 0.3 g/kg/day CHO, 63%CHO, 1162 kcal/day). During the three consecutive days of the dietary intervention program, participants consumed only the prescribed diet and maintained their habitual physical activity levels. Body composition, substrate oxidation, iron metabolism, and inflammation were evaluated pre- and post-intervention. Serum iron and ferritin levels were significantly elevated following the intervention (p < 0.001, p = 0.003, respectively). Plasma interleukin-6 (IL-6) levels did not change following the intervention. Serum hepcidin levels significantly increased after the intervention (p = 0.002). Relative change in hepcidin levels was significantly higher in the ED + LCHO (264.3 ± 87.2%) than in the ED group (68.9 ± 22.1%, p = 0.048). Three consecutive days of an energy-deficient diet increased fasting hepcidin levels. Moreover, elevated hepcidin levels were further augmented when an energy-deficient diet was combined with a lower CHO intake.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Physiological reports
- 巻
- 10
- 号
- 13
- 開始ページ
- e15351
- 終了ページ
- 出版年月
- 2022年7月
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.14814/phy2.15351
- 共同研究・競争的資金等の研究課題