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最終更新日：2024/04/19
妙圎園 香苗
ミョウエンゾノ カナエ
(Kanae Myoenzono)
論文
- タイトル
- タイトル（英）
- Associations of circulating xanthine oxidoreductase activity with cardiometabolic risk markers in overweight and obese Japanese men: a cross-sectional pilot study
- 参照URL
- https://researchmap.jp/myoenzonokanae/published_papers/36308531
- 著者
- 著者（英）
- Keisei Kosaki,Atsumu Yokota,Koichiro Tanahashi,Kanae Myoenzono,Jiyeon Park,Toru Yoshikawa,Yasuko Yoshida,Takayo Murase,Seigo Akari,Takashi Nakamura,Seiji Maeda
- 担当区分
- 概要
- 概要（英）
- Circulating xanthine oxidoreductase (XOR) activity may contribute to the pathogenesis of obesity-related adverse cardiometabolic profiles. This pilot study aimed to examine the cross-sectional associations between plasma XOR activity and cardiometabolic risk (CMR) markers in overweight and obese men. In 64 overweight and obese Japanese men (aged 31-63 years), plasma XOR activity and several CMR markers, such as homeostasis model assessment of insulin resistance (HOMA-IR), and clustered CMR score were measured in each participant. Clustered CMR score was constructed based on waist circumference, triglyceride, blood pressure, fasting plasma glucose, and high-density lipoprotein cholesterol. Plasma XOR activity in overweight and obese men was positively associated with the body mass index, waist circumference, visceral fat area, body fat mass, hemoglobin A1c, serum 8-hydroxy-2'-deoxyguanosine, HOMA-IR, and clustered CMR score and was inversely associated with handgrip strength and high-density lipoprotein cholesterol. Multiple linear regression analysis further demonstrated that the associations of plasma XOR activity with HOMA-IR and the clustered CMR score remained significant after adjustment for covariates including uric acid. Our data demonstrate that circulating XOR activity was independently associated, albeit modestly, with HOMA-IR and the clustered CMR score. These preliminary findings suggest that circulating XOR activity can potentially be one of the preventive targets and biomarkers of cardiometabolic disorders in over-weight and obese men.
- 出版者・発行元
- 出版者・発行元（英）
- The Society for Free Radical Research Japan
- 誌名
- 誌名（英）
- Journal of Clinical Biochemistry and Nutrition
- 巻
- 71
- 号
- 2
- 開始ページ
- 122
- 終了ページ
- 128
- 出版年月
- 2022年1月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0912-0009
- DOI URL
- https://doi.org/10.3164/jcbn.21-118
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