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最終更新日：2025/07/02
竹村 藍
タケムラ アイ
(Ai Takemura)
論文
- タイトル
- タイトル（英）
- Differential Mitochondrial Adaptation of the Slow and Fast Skeletal Muscles by Endurance Running Exercise in Streptozotocin-Induced Diabetic Mice
- 参照URL
- https://researchmap.jp/Atakemura/published_papers/50518156
- 著者
- 著者（英）
- A Takemura,Y Matsunaga,T Shinya,H Hatta
- 担当区分
- 筆頭著者,責任著者
- 概要
- 概要（英）
- The skeletal muscle is the main organ responsible for insulin action, and glucose disposal and metabolism. Endurance and/or resistance training raises the number of mitochondria in diabetic muscles. The details of these adaptations, including mitochondrial adaptations of the slow and fast muscles in diabetes, are unclear. This study aimed to determine whether exercise training in streptozotocin (STZ)-induced mice leads to differential adaptations in the slow and fast muscles, and improving glucose clearance. Eight-week-old mice were randomly distributed into normal control (CON), diabetes (DM), and diabetes and exercise (DM+Ex) groups. In the DM and DM+Ex groups, mice received a freshly prepared STZ (100 mg/kg) intraperitoneal injection on two consecutive days. Two weeks after the injection, the mice in the groups ran on a treadmill for 60 min at 20 m/min for a week and subsequently at 25 m/min for 5 weeks (5 days/week). The analyses indicated that running training at low speed (25 m/min) enhanced mitochondrial enzyme activity and expression of lactate and glucose transporters in the plantaris (low-oxidative) muscle that improved whole-body glucose metabolism in STZ-induced diabetic mice. There were no differences in glucose transporter expression levels in the soleus (high-oxidative) muscle. The endurance running exercise at 20-25 m/min was sufficient to induce mitochondrial adaptation in the low-oxidative muscles, but not in the high-oxidative muscles, of diabetic mice. In conclusion, the present study indicated that running training at 25 m/min improved glucose metabolism by increasing the mitochondrial enzyme activity and glucose transporter 4 and monocarboxylate transporter 4 protein contents in the low-oxidative muscles in STZ-induced diabetic mice.
- 出版者・発行元
- 出版者・発行元（英）
- Institute of Physiology of the Czech Academy of Sciences
- 誌名
- 誌名（英）
- Physiological Research
- 巻
- 号
- 3/2024
- 開始ページ
- 369
- 終了ページ
- 379
- 出版年月
- 2024年7月10日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 0862-8408
- DOI URL
- https://doi.org/10.33549/physiolres.935183
- 共同研究・競争的資金等の研究課題