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最終更新日：2024/11/12
塩瀬 圭佑
シオセ ケイスケ
(Keisuke Shiose)
論文
- タイトル
- タイトル（英）
- Greater energy surplus promotes body protein accretion in healthy young men: A randomized clinical trial.
- 参照URL
- https://researchmap.jp/k.shiose/published_papers/48323892
- 著者
- 著者（英）
- Yoichi Hatamoto,Yukiya Tanoue,Ryoichi Tagawa,Jun Yasukata,Keisuke Shiose,Yujiro Kose,Daiki Watanabe,Shigeho Tanaka,Kong Y Chen,Naoyuki Ebine,Keisuke Ueda,Yoshinari Uehara,Yasuki Higaki,Chiaki Sanbongi,Kentaro Kawanaka
- 担当区分
- 概要
- 概要（英）
- BACKGROUND & AIMS: Caloric overfeeding combined with adequate protein intake increases not only body fat mass but also fat-free mass. However, it remains unclear whether the increase in fat-free mass due to overfeeding is associated with an increase in total body protein mass. We evaluated the hypothesis that overfeeding would promote an increase in total body protein mass. METHODS: In our randomized controlled trial, 23 healthy young men were fed a diet equivalent to their energy requirements with a +10 % energy surplus from protein alone or a +40 % energy surplus (+10 % from protein, +30 % from carbohydrate) for 6 weeks. We estimated total body protein mass by a four-compartment model using dual-energy X-ray absorptiometry, deuterium dilution, and hydrostatic underwater weighing. RESULTS: The 40 % energy surplus over 6 weeks significantly increased body protein mass compared to baseline by 3.7 % (0.44 kg; 95 % confidence interval [CI], 0.21-0.67 kg; P = 0.003); however, the 10 % energy surplus did not result in a significant change (0.00 kg; 95 % CI, -0.38-0.39 kg; P = 0.980). A significant interaction between intervention duration (time) and energy surplus (group) was observed for total body protein mass (P = 0.035, linear mixed-effects model), with a trend toward a significant difference in total body protein mass gain between groups (P = 0.059, Wilcoxon rank sum test). The increase in body protein mass due to the energy surplus was correlated with an increase in fat mass (r = 0.820, p = 0.002). CONCLUSIONS: A higher energy intake was found to promote an increase in body protein mass in healthy men consuming excess protein, suggesting the importance of energy surplus in body protein accumulation. This effect of energy surplus may be related to factors such as increased body fat mass and the associated secretion of adipokines. TRIAL REGISTRATION: The trial was registered with the University Hospital Medical Information Network Clinical Trial Registry as UMIN000034158.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Clinical nutrition (Edinburgh, Scotland)
- 巻
- 43
- 号
- 12
- 開始ページ
- 48
- 終了ページ
- 60
- 出版年月
- 2024年9月30日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1016/j.clnu.2024.09.035
- 共同研究・競争的資金等の研究課題