News
人材検索について
ハイパフォーマンススポーツに係る研究者やサポートスタッフ等の人材情報の検索ができます。HPSCに現在勤務する職員（HPSCスタッフ）、HPSCの勤務経験者（HPSC OB/OG）、HPSCの各種事業における協力者（HPSC事業協力者）のカテゴリーに分けております。人材データベースへのご登録はHPSCからご依頼させて頂いた方のみとしております。
最終更新日：2025/04/11
本間 洋樹
ホンマ ヒロキ
(Hiroki Homma)
論文
- タイトル
- タイトル（英）
- Effect of the ACTN3 R577X Polymorphism on Serum Creatine Kinase and Interleukin-6 Levels after Maximal Eccentric Exercise.
- 参照URL
- https://researchmap.jp/h-homma0145/published_papers/48001024
- 著者
- 著者（英）
- Minoru Deguchi,Hiroki Homma,Kathleen Y de Almeida,Ayumu Kozuma,Mika Saito,Yosuke Tsuchiya,Karina Kouzaki,Eisuke Ochi,Takanobu Okamoto,Koichi Nakazato,Naoki Kikuchi
- 担当区分
- 概要
- 概要（英）
- OBJECTIVE: This study explored the interaction among ACTN3 R577X polymorphism, muscle damage, and post-exercise inflammatory response by assessing changes over time in serum creatine kinase and interleukin-6 levels. DESIGN: Ninety-five active Japanese participants (50 men and 45 women: 22.2 ± 2.3 years) who did not perform daily upper limb strength exercises were enrolled. Participants executed five sets of six maximal eccentric elbow flexion exercises. The exercise duration was 9 min, including rest between sets (90 s). Maximum voluntary isometric contraction, range of motion, muscle soreness, and serum creatine kinase and interleukin-6 levels were assessed pre and post and 1, 2, 3, and 5 d after exercise. Genotype groups were classified as RR + RX and XX based on the absence of ACTN3 expression. RESULTS: A significant time and group interaction (p = 0.045) on creatine kinase levels was observed between the groups, indicating that the absence of ACTN3 significantly affects creatine kinase changes. Conversely, no significant interaction on change in interleukin-6, maximum voluntary isometric contraction, range of motion, and muscle soreness was observed between groups. CONCLUSION: The results highlight an interaction on creatine kinase activity post-exercise by ACTN3 R577X polymorphism, with elevated activity in the XX genotype.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- American journal of physical medicine & rehabilitation
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年9月16日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1097/PHM.0000000000002623
- 共同研究・競争的資金等の研究課題