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最終更新日：2024/02/05
宮本 直和
ミヤモト ナオカズ
(Naokazu Miyamoto)
論文
- タイトル
- Effects of resistance training intensity on muscle quantity/quality in middle-aged and older people: a randomized controlled trial
- タイトル（英）
- Effects of resistance training intensity on muscle quantity/quality in middle-aged and older people: a randomized controlled trial
- 参照URL
- https://researchmap.jp/read0094733/published_papers/36742683
- 著者
- Yuta Otsuka,Yosuke Yamada,Akifumi Maeda,Takayuki Izumo,Tomohiro Rogi,Hiroshi Shibata,Masahiro Fukuda,Takuma Arimitsu,Naokazu Miyamoto,Takeshi Hashimoto
- 著者（英）
- Yuta Otsuka,Yosuke Yamada,Akifumi Maeda,Takayuki Izumo,Tomohiro Rogi,Hiroshi Shibata,Masahiro Fukuda,Takuma Arimitsu,Naokazu Miyamoto,Takeshi Hashimoto
- 担当区分
- 概要
- 概要（英）
- BACKGROUND: A sarcopenia diagnosis is confirmed by the presence of low muscle quantity or quality under the 2018 revised definition by the European Working Group on Sarcopenia in Older People 2. Imaging methods [i.e. magnetic resonance imaging (MRI)], dual-energy X-ray absorptiometry (DXA), and bioelectrical impedance analysis are tools to evaluate muscle quantity or quality. The present study aimed to investigate whether and how low-intensity and moderate-intensity resistance training improved both muscle quantity and quality measured by MRI, DXA, and segmental bioelectrical impedance spectroscopy (S-BIS) in middle-aged and older people. METHODS: A single-blind, randomized, controlled trial was conducted. Community-dwelling people aged 50-79 years were randomly allocated to no exercise (no-Ex), low-intensity exercise (low-Ex), and moderate-intensity exercise (moderate-Ex) groups. Participants in the exercise groups performed resistance training for 24 weeks, with loads of 40% and 60% of one repetition maximum in the low-Ex and moderate-Ex groups, respectively. Cross-sectional area (CSA), lean mass, and muscle electrical properties on S-BIS were used to determine the effects of training interventions on muscle quantity and quality of the lower limbs. RESULTS: Fifty participants (no-Ex 17, age 63.5 ± 8.5 years, women 47.1%; low-Ex 16, age 63.6 ± 8.1 years, women 50.0%; moderate-Ex 17, age 63.5 ± 8.3 years, women 52.9%) completed the 24 week exercise intervention. For the primary outcome, significant intervention effects were found in thigh muscle CSA on MRI between the moderate-Ex and no-Ex groups (+6.8 cm2 , P < 0.01). Low-Ex for 24 weeks only increased quadriceps CSA (+2.3 cm2 , P < 0.05). The per cent change of thigh muscle CSA (+7.0%, P < 0.01) after 24 week moderate-Ex was higher than that of leg lean mass on DXA (+2.3%, P = 0.088). Moderate-Ex for 24 weeks also improved S-BIS electrical properties related to muscle quantity and quality, including the intracellular resistance index (+0.1 cm2 /Ω, P < 0.05), membrane capacitance (+0.7 nF, P < 0.05), and phase angle (+0.3 deg, P < 0.05); their changes were positively correlated with that of thigh muscle CSA (P < 0.01). CONCLUSIONS: Resistance exercise with moderate intensity improved muscle quantity and quality measured by MRI and S-BIS, whereas that with low intensity only increased muscle quantity in middle-aged and older people. The comparisons among the responses to exercise between the assessment methods indicate the greater value of MRI and S-BIS to measure changes of muscle quantity and quality than of lean mass measured by DXA for assessing the local effects of resistance training.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- Journal of Cachexia, Sarcopenia and Muscle
- 誌名（英）
- Journal of cachexia, sarcopenia and muscle
- 巻
- 13
- 号
- 2
- 開始ページ
- 894
- 終了ページ
- 908
- 出版年月
- 2022年4月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1002/jcsm.12941
- 共同研究・競争的資金等の研究課題