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最終更新日：2026/10/14
石垣 智恒
イシガキ トモノブ
(Tomonobu Ishigaki)
論文
- タイトル
- タイトル（英）
- Potential Usefulness of Urinary Hepcidin Measurement for Iron Deficiency Anemia in Female Athletes
- 参照URL
- https://researchmap.jp/ishi-gaki/published_papers/53810965
- 著者
- 著者（英）
- Haruo Hanawa,Hiromi Inaba,Fumi Hoshino,Mutsuaki Edama,Chie Sekine,Takanori Kikumoto,Tomonobu Ishigaki,Yuiko Matsuura,Go Omori
- 担当区分
- 概要
- 概要（英）
- ABSTRACT Hepcidin is a key regulator of iron metabolism and has been proposed as a biomarker for detecting iron deficiency. This study examined serum hepcidin and non‐invasively measured urinary hepcidin in 260 female athletes to assess their potential utility in evaluating iron status. Urinary hepcidin/creatinine showed a strong correlation with serum hepcidin and was positively associated with ferritin, suggesting that it reflects underlying iron dynamics. Iron‐related measures, including hepcidin, showed expected differences across iron‐status categories, consistent with physiological changes from iron repletion to iron deficiency anemia. In diagnostic analyses, both serum hepcidin and urinary hepcidin/creatinine demonstrated good accuracy for identifying iron deficiency including iron deficiency anemia. Serum hepcidin yielded AUCs of approximately 0.85–0.90, while urinary hepcidin/creatinine showed AUCs around 0.85–0.88. Internal validation produced consistent confidence intervals, suggesting stable estimates. At the Youden‐optimal cutoff, both markers showed comparable performance, with sensitivities of 0.74–0.91, specificities of 0.73–0.92, and high negative predictive values (0.83–0.97). These cutoff values were derived from internally validated analyses and should be considered preliminary, requiring external validation before broader clinical implementation. These findings suggest that hepcidin‐based measures may assist in ruling out iron deficiency or guiding triage decisions. Because urinary hepcidin can be obtained non‐invasively and demonstrated performance similar to serum hepcidin, it may represent a practical screening option in athletic populations, although further external validation is needed.
- 出版者・発行元
- 出版者・発行元（英）
- Wiley
- 誌名
- 誌名（英）
- European Journal of Sport Science
- 巻
- 26
- 号
- 6
- 開始ページ
- 終了ページ
- 出版年月
- 2026年5月22日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 1746-1391
- DOI URL
- https://doi.org/10.1002/ejsc.70198
- 共同研究・競争的資金等の研究課題