最終更新日：2026/08/20
笠井 信一
カサイ ノブカズ
(Nobukazu Kasai)
論文
- タイトル
- タイトル（英）
- Eight weeks of high-intensity interval training is insufficient to prevent sitting-induced endothelial dysfunction and microvascular impairment.
- 参照URL
- https://researchmap.jp/nobukazuK100/published_papers/54688979
- 著者
- 著者（英）
- Nobukazu Kasai,Hayato Ihara,Motoyuki Iemitsu,Takuma Morishima
- 担当区分
- 概要
- 概要（英）
- Prolonged sitting disrupts lower-limb endothelial and microvascular function, likely via reduced shear stress and blunted microvascular reactivity. We examined whether Tabata-style high-intensity interval training (HIIT) mitigates this sitting-induced vascular dysfunction. Twenty-two healthy young adults (age 20.3 ± 0.8 years) were randomly assigned to a control group (n = 11) or a training group (n = 11); each group comprised seven men and four women. Participants completed 8 weeks of HIIT (4 sessions/week) using a cycle ergometer and bodyweight exercises. Before and after the intervention, participants underwent a 3 h period of sitting during which popliteal artery flow-mediated dilation (FMD) and reactive hyperaemic blood flow were assessed; plasma nitrate/nitrite and endothelin-1 were also measured at rest. Sitting reduced popliteal artery blood flow and shear rate in both groups before and after training (P < 0.05). Popliteal artery FMD decreased after sitting at baseline in both groups and remained lower after sitting in the training group post-intervention. However, post-sitting FMD at week 8 was higher in the HIIT group than in controls after adjustment for pre-sitting FMD. Post-sitting blood-flow area under the curve was decreased by sitting in both groups before and after the intervention (P < 0.05), and resting nitrate/nitrite and endothelin-1 did not change with training. These results indicate that 8 weeks of HIIT does not prevent sitting-induced impairments in endothelial function or microvascular function. Although the HIIT maintained higher post-sitting FMD, HIIT alone was insufficient to counteract the acute endothelial and microvascular dysfunction imposed by sitting.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Experimental physiology
- 巻
- 111
- 号
- 7
- 開始ページ
- 3242
- 終了ページ
- 3252
- 出版年月
- 2026年7月
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1113/EP093646
- 共同研究・競争的資金等の研究課題
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