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最終更新日：2026/06/17
松浦 由生子
(Matsuura Yuiko)
論文
- タイトル
- タイトル（英）
- Potential Usefulness of Urinary Hepcidin Measurement for Iron Deficiency Anemia in Female Athletes.
- 参照URL
- https://researchmap.jp/yik/published_papers/53740293
- 著者
- 著者（英）
- Haruo Hanawa,Hiromi Inaba,Fumi Hoshino,Mutsuaki Edama,Chie Sekine,Takanori Kikumoto,Tomonobu Ishigaki,Yuiko Matsuura,Go Omori
- 担当区分
- 概要
- 概要（英）
- Hepcidin is a key regulator of iron metabolism and has been proposed as a biomarker for detecting iron deficiency. This study examined serum hepcidin and non-invasively measured urinary hepcidin in 260 female athletes to assess their potential utility in evaluating iron status. Urinary hepcidin/creatinine showed a strong correlation with serum hepcidin and was positively associated with ferritin, suggesting that it reflects underlying iron dynamics. Iron-related measures, including hepcidin, showed expected differences across iron-status categories, consistent with physiological changes from iron repletion to iron deficiency anemia. In diagnostic analyses, both serum hepcidin and urinary hepcidin/creatinine demonstrated good accuracy for identifying iron deficiency including iron deficiency anemia. Serum hepcidin yielded AUCs of approximately 0.85-0.90, while urinary hepcidin/creatinine showed AUCs around 0.85-0.88. Internal validation produced consistent confidence intervals, suggesting stable estimates. At the Youden-optimal cutoff, both markers showed comparable performance, with sensitivities of 0.74-0.91, specificities of 0.73-0.92, and high negative predictive values (0.83-0.97). These cutoff values were derived from internally validated analyses and should be considered preliminary, requiring external validation before broader clinical implementation. These findings suggest that hepcidin-based measures may assist in ruling out iron deficiency or guiding triage decisions. Because urinary hepcidin can be obtained non-invasively and demonstrated performance similar to serum hepcidin, it may represent a practical screening option in athletic populations, although further external validation is needed.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- European journal of sport science
- 巻
- 26
- 号
- 6
- 開始ページ
- e70198
- 終了ページ
- 出版年月
- 2026年6月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1002/ejsc.70198
- 共同研究・競争的資金等の研究課題