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最終更新日：2026/06/16
今井 菜美
イマイ ナミ
(Nami Imai)
論文
- タイトル
- タイトル（英）
- Incident subclinical vertebral fractures and health-related quality of life: JPOS cohort study.
- 参照URL
- https://researchmap.jp/imai_n/published_papers/54064247
- 著者
- 著者（英）
- Mayumi Uesaka,Masami Hamada,Takahiro Tachiki,Yuho Sato,Kouji Tsuda,Asako Kudo,Kuniyasu Kamiya,Nami Imai,Akemi Nitta,Miho Tanaka,Kumiko Ohara,Naoyuki Takashima,Jun Kitagawa,Katsuyasu Kouda,Akemi Morita,Kazuhiro Uenishi,Etsuko Kajita,Koji Tamakoshi,Sadanobu Kagamimori,Junko Tamaki,Masayuki Iki
- 担当区分
- 概要
- 概要（英）
- INTRODUCTION: Vertebral fractures are the most common osteoporotic fractures, yet approximately two-thirds of radiographically detectable fractures remain clinically unrecognized. The longitudinal impact of such subclinical vertebral fractures on health-related quality of life (HRQOL) is not fully clarified. This study examined whether incident subclinical vertebral fractures were associated with subsequent changes in HRQOL. MATERIALS AND METHODS: This study was nested within the Japanese Population-based Osteoporosis (JPOS) Cohort. Community-dwelling women aged ≥ 50 years without clinical fractures were included. Incident subclinical vertebral fractures, assessed by single-energy X-ray absorptiometry-based vertebral fracture assessment with morphometry, were the primary exposure. HRQOL was evaluated using Japanese SF-36® v2. General linear models estimated associations between incident fractures and follow-up SF-36® subscale scores, adjusting for baseline HRQOL and prespecified covariates. Sensitivity analyses excluding participants with pre-baseline subclinical vertebral fractures or with anti-osteoporosis medication were performed. RESULTS: Of 344 participants, 53 (15.4%) developed incident subclinical vertebral fractures. Baseline SF-36® standardized subscale scores did not differ between groups. At follow-up, women with incident fractures had significantly lower physical functioning and social functioning scores. After multivariable adjustment, social functioning remained significantly lower in the fracture group (false discovery rate-adjusted p = 0.028). Social functioning declined progressively with increasing fracture number and was significantly lower in lumbar fractures. Sensitivity analyses yielded consistent results with primary analyses. CONCLUSIONS: Incident subclinical vertebral fractures among community-dwelling Japanese women were independently associated with clinically meaningful declines in social functioning, suggesting the importance of early identification to prevent deterioration in HRQOL.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Journal of bone and mineral metabolism
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2026年4月10日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1007/s00774-026-01721-3
- 共同研究・競争的資金等の研究課題