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最終更新日：2026/04/15
門口 智泰
(Tomoyasu Kadoguchi)
論文
- タイトル
- タイトル（英）
- Accumulation of polyunsaturated fatty acid-derived metabolites in the sarcopenic muscle of aging mice.
- 参照URL
- https://researchmap.jp/m-s-m-i/published_papers/41534288
- 著者
- 著者（英）
- Tomoyasu Kadoguchi,Kazunori Shimada,Naoshi Fukui,Nobuho Tanaka,Hirotaka Tsuno,Tomoyuki Shiozawa,Kosuke Fukao,Miho Nishitani-Yokoyama,Kikuo Isoda,Satoshi Matsushita,Norihiko Yokoyama,Hiroyuki Daida
- 担当区分
- 筆頭著者,責任著者
- 概要
- 概要（英）
- AIM: Although it is known that advanced age alters skeletal muscle lipid metabolism, the role(s) of polyunsaturated fatty acid-derived metabolites (mostly eicosanoids and docosanoids) in sarcopenia are not clear. We therefore examined the changes in the metabolites of arachidonic acid, eicosapentaenoic acid and docosahexaenoic acid in the sarcopenic muscle of aged mice. METHODS: We used 6- and 24-month-old male C57BL/6J mice as healthy and sarcopenic muscle models, respectively. Skeletal muscles were removed from the lower limb and subjected to a liquid chromatography-tandem mass spectrometry analysis. RESULTS: The liquid chromatography-tandem mass spectrometry analysis detected distinct changes of metabolites in the muscles of the aged mice. Of the 63 metabolites identified, nine were significantly higher in the sarcopenic muscle of aged mice compared with the healthy muscle of young mice. In particular, prostaglandin E2 , prostaglandin F2a , thromboxane B2 , 5-hydroxyeicosatetraenoic acid, and 15-oxo-eicosatetraenoic acid (arachidonic acid-derived metabolites), 12-hydroxy-eicosapentaenoic acid and 14,15-epoxy-eicosatetraenoic acid (eicosapentaenoic acid-derived metabolites) and 10-hydroxydocosa-hexaenoic acid and 14-hydroxyoctadeca-pentaenoic acid (docosahexaenoic acid-derived metabolites) were significantly higher in aged tissue compared with young tissue (all P < 0.05). CONCLUSIONS: We observed the accumulation of metabolites in the sarcopenic muscle of aged mice. Our results may provide new insights into the pathogenesis and progression of aging- or disease-related sarcopenia. Geriatr Gerontol Int ••; ••: ••-•• Geriatr Gerontol Int 2023; ••: ••-••.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Geriatrics & gerontology international
- 巻
- 23
- 号
- 4
- 開始ページ
- 297
- 終了ページ
- 303
- 出版年月
- 2023年2月22日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1111/ggi.14561
- 共同研究・競争的資金等の研究課題