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最終更新日:2026/03/16

能瀬 さやか

(Sayaka Nose-Ogura)
論文
タイトル
タイトル(英)
Development and validation of a pre-screening tool for early detection of low bone mineral density in female athletes (PreST-LBMD).
参照URL
https://researchmap.jp/ns0301/published_papers/52228751
著者
著者(英)
Sayaka Nose-Ogura,Osamu Yoshino,Sakiko Kinoshita,Hiroe Nakamura-Kamoto,Katsuyuki Tabei,Takayuki Komatsu,Ayano Hamai,Kengo Iida,Takako Koshimizu,Haruo Nakayama,Hiroto Fujiya,Tomohiro Manabe,Fumihiro Yamasawa,João Gabriel Segato Kruse,Miki Kaneko,Miyuki Harada,Osamu Hiraike,Haruki Musha,Ken Kiyono,Yutaka Osuga,Kohei Nakajima
担当区分
概要
概要(英)
BACKGROUND: The prevalence of low bone mineral density (BMD) among female athletes is higher than that among their male counterparts up to 40%. Low BMD increases the risk of stress fractures. PURPOSE: To examine factors associated with low BMD in female athletes, and to develop, test, and evaluate a Pre-screening Tool for Early Detection of Low BMD in Female Athletes (PreST-LBMD). METHOD: The development and validation groups (381 and 233 subjects, respectively) underwent a medical interview and a BMD test at the lumbar spine using dual-energy X-ray absorptiometry (DXA). A Z-score < -1 was classified as low BMD. After extracting factors associated with low BMD from univariate logistic regression and multivariate least absolute shrinkage and selection operator (LASSO) regression analyses, each variable was scored based on the β coefficients from LASSO regression to create the PreST-LBMD. The development model was validated using receiver operating characteristic (ROC) curves. Furthermore, using external validation data, sensitivity, negative predictive value (NPV), and area under the curve (AUC) were calculated to evaluate the performance of PreST-LBMD. RESULT: Factors associated with low BMD included age at menarche, amenorrhea for more than 1 year during the teenage years, current duration of amenorrhea, body mass index, history of stress fractures, and exercise load. The calculated cutoff value for a high likelihood of low BMD was 3 points, with a sensitivity of 0.83 (0.79-0.88), a negative predictive value of 0.85 (0.81-0.90), and an area under the curve of 0.74 (0.67-0.81). CONCLUSION:  We successfully developed the PreST-LBMD, which showed promising results identifying female athletes with low BMD. Those scoring ≥3 should be assessed by DXA and evaluated for the likelihood of low BMD by the athlete's health and performance team.
出版者・発行元
出版者・発行元(英)
誌名
誌名(英)
The Physician and sportsmedicine
54
1
開始ページ
63
終了ページ
74
出版年月
2026年2月
査読の有無
招待の有無
掲載種別
研究論文(学術雑誌)
ISSN
DOI URL
https://doi.org/10.1080/00913847.2025.2586448
共同研究・競争的資金等の研究課題