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最終更新日：2026/03/09
本間 洋樹
ホンマ ヒロキ
(Hiroki Homma)
論文
- タイトル
- タイトル（英）
- Association of the GALNTL6 rs558129 polymorphism with muscle strength in Japanese athletes.
- 参照URL
- https://researchmap.jp/h-homma0145/published_papers/52256244
- 著者
- 著者（英）
- Ayumu Kozuma,Eri Miyamoto-Mikami,Mika Saito,Hiroki Homma,Minoru Deguchi,Shingo Matsumoto,Ryutaro Matsumoto,Takanobu Okamoto,Koichi Nakazato,Noriyuki Fuku,Naoki Kikuchi
- 担当区分
- 概要
- 概要（英）
- The significance of GALNTL6 rs558129 polymorphism in relation to muscle strength and power performance has been reported in several studies. However, there has been no replication study in the Japanese population. Therefore, in this study, we aimed to determine the association of GALNTL6 rs558129 polymorphism with athlete status and muscle strength in Japanese athletes. In study 1, genotype frequencies were compared between 376 power-oriented athletes (male: n = 257, female: n = 119) and 1,139 controls (male: n = 448, female: n = 691). The power-oriented athletes included wrestlers (n = 146), weightlifters (n = 151) and power lifters (n = 79). In study 2, isokinetic knee extension and flexion muscle strength tests were performed in 347 athletes (male: n = 298, female: n = 49). In both studies, GALNTL6 rs558129 polymorphism was identified using the TaqMan SNP Genotyping Assay. In study 1, there were no significant differences in genotype frequencies between the power-oriented athletes and controls. However, the frequency of TT genotype was significantly higher in wrestlers compared to controls (p = 0.044). In study 2, isokinetic knee extension muscle strength was significantly higher in athletes with the T allele than in athletes with the CC genotype (p = 0.012). In addition, a significant tendency of the isokinetic knee extension muscle strength was observed in the CC, CT, and TT genotype, respectively. The results of this study suggest that the TT genotype and T allele of GALNTL6 polymorphism are associated with knee extension muscle strength in Japanese athletes and that the TT genotype is observed at a higher frequency in Japanese wrestlers. These findings are consistent with and further validate the results of previous studies.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Biology of sport
- 巻
- 42
- 号
- 3
- 開始ページ
- 161
- 終了ページ
- 167
- 出版年月
- 2025年7月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.5114/biolsport.2025.147010
- 共同研究・競争的資金等の研究課題