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最終更新日：2026/03/09
本間 洋樹
ホンマ ヒロキ
(Hiroki Homma)
論文
- タイトル
- タイトル（英）
- Genetic Factors of Elite Wrestling Status: A Multi-Ethnic Comparative Study.
- 参照URL
- https://researchmap.jp/h-homma0145/published_papers/52256243
- 著者
- 著者（英）
- Ayumu Kozuma,Celal Bulgay,Hirofumi Zempo,Mika Saito,Minoru Deguchi,Hiroki Homma,Shingo Matsumoto,Ryutaro Matsumoto,Anıl Kasakolu,Hasan H Kazan,Türker Bıyıklı,Seyrani Koncagül,Giyasettin Baydaş,Mehmet A Ergun,Attila Szabo,Ekaterina A Semenova,Andrey K Larin,Nikolay A Kulemin,Edward V Generozov,Takanobu Okamoto,Koichi Nakazato,Ildus I Ahmetov,Naoki Kikuchi
- 担当区分
- 概要
- 概要（英）
- BACKGROUND: In recent years, comprehensive analyses using a genome-wide association study (GWAS) have been conducted to identify genetic factors related to athletic performance. In this study, we investigated the association between genetic variants and elite wrestling status across multiple ethnic groups using a genome-wide genotyping approach. METHODS: This study included 168 elite wrestlers (64 Japanese, 67 Turkish, and 36 Russian), all of whom had competed in international tournaments, including the Olympic Games. Control groups consisted of 306 Japanese, 137 Turkish, and 173 Russian individuals without elite athletic backgrounds. We performed a GWAS comparing allele frequencies of single-nucleotide polymorphisms (SNPs) between elite wrestlers and controls in each ethnic cohort. Cross-population analysis comprised (1) identifying SNPs with nominal significance (p < 0.05) in all three groups, then (2) meta-analyzing overlapped SNPs to assess effect consistency and combined significance. Finally, we investigated whether the most significant SNPs were associated with gene expression in skeletal muscle in 23 physically active men. RESULTS: The GWAS identified 328,388 (Japanese), 23,932 (Turkish), and 30,385 (Russian) SNPs reaching nominal significance. Meta-analysis revealed that the ATP2A3 rs6502758 and UNC5C rs265061 polymorphisms were associated (p < 0.0001) with elite wrestling status across all three populations. Both variants are located in intronic regions and influence the expression of their respective genes in skeletal muscle. CONCLUSIONS: This is the first study to investigate gene polymorphisms associated with elite wrestling status in a multi-ethnic cohort. ATP2A3 rs6502758 and UNC5C rs265061 polymorphisms may represent important genetic factors associated with achieving an elite status in wrestling, irrespective of ethnicity.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Genes
- 巻
- 16
- 号
- 8
- 開始ページ
- 終了ページ
- 出版年月
- 2025年7月29日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3390/genes16080906
- 共同研究・競争的資金等の研究課題