人材検索について
ハイパフォーマンススポーツに係る研究者やサポートスタッフ等の人材情報の検索ができます。HPSCに現在勤務する職員（HPSCスタッフ）、HPSCの勤務経験者（HPSC OB/OG）、HPSCの各種事業における協力者（HPSC事業協力者）のカテゴリーに分けております。人材データベースへのご登録はHPSCからご依頼させて頂いた方のみとしております。
最終更新日：2025/11/20
今井 菜美
イマイ ナミ
(Nami Imai)
論文
- タイトル
- タイトル（英）
- Joint association of milk intake and blood 25(OH)D levels with fracture risk in postmenopausal women: 20-year follow-up data from the Japanese Population-Based Osteoporosis cohort study.
- 参照URL
- https://researchmap.jp/imai_n/published_papers/51695756
- 著者
- 著者（英）
- Kuniyasu Kamiya,Akane Kojima,Takahiro Tachiki,Nami Imai,Katsuyasu Kouda,Masami Hamada,Asako Kudo,Kouji Tsuda,Akiko Hata,Kumiko Ohara,Naoyuki Takashima,Yuho Sato,Miho Tanaka,Jun Kitagawa,Kazuhiro Uenishi,Junko Tamaki,Etsuko Kajita,Sadanobu Kagamimori,Toshio Matsumoto,Masayuki Iki
- 担当区分
- 概要
- 概要（英）
- UNLABELLED: The associations between milk intake frequency and fracture risk in groups categorized by 25(OH)D levels were investigated using 20-year follow-up data. A significant association was observed only among women with 25(OH)D levels < 15 ng/mL. The measurement of blood 25(OH)D levels should be prioritized for individuals with low milk intake. PURPOSE: To investigate the association between milk intake frequency and fracture risk in groups based on blood 25(OH)D levels. METHODS: This secondary analysis of a prospective cohort study included data from 1209 postmenopausal Japanese women aged ≥ 50 years. Baseline milk intake frequency was obtained using a questionnaire. Blood 25(OH)D levels were measured using a competitive protein-binding assay. Information on fracture events was obtained from face-to-face interviews through follow-up or supplemental mail surveys. RESULTS: Over a median follow-up period of 16.1 years (total: 17,427 person-years), 358 and 238 women sustained at least one clinical and osteoporotic fracture, respectively. The proportions of participants with milk intake < 1 glass/day and those with 25(OH)D levels < 15 ng/mL were 31.9% and 21.6%, respectively. In univariate Cox proportional hazard analyses, a 25(OH)D level < 15 ng/mL and a milk intake of < 1 glass/day were associated with an increased risk of clinical and osteoporotic fractures. Among participants with 25(OH)D levels < 15 ng/mL, the adjusted hazard ratios for milk intake < 1 glass/day compared to ≥ 1 glass/day were 1.99 (95% confidence interval: 1.32-2.99) and 2.11 (1.28-3.47) for clinical and osteoporotic fractures, respectively. In contrast, the HRs were not significant among those with 25(OH)D levels ≥ 15 ng/mL. CONCLUSION: A clear positive association was identified between milk intake frequency and fracture risk among Japanese women after menopause with low 25(OH)D levels. Therefore, correcting vitamin D insufficiency would likely lower fracture risk. In addition, encouraging habitual milk intake may help prevent fractures, particularly among individuals with low 25(OH)D levels.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
- 巻
- 36
- 号
- 8
- 開始ページ
- 1447
- 終了ページ
- 1458
- 出版年月
- 2025年8月
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1007/s00198-025-07577-z
- 共同研究・競争的資金等の研究課題