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最終更新日：2025/04/11
本間 洋樹
ホンマ ヒロキ
(Hiroki Homma)
論文
- タイトル
- タイトル（英）
- Identification of Genomic Predictors of Muscle Fiber Size.
- 参照URL
- https://researchmap.jp/h-homma0145/published_papers/47335864
- 著者
- 著者（英）
- João Paulo L F Guilherme,Ekaterina A Semenova,Naoki Kikuchi,Hiroki Homma,Ayumu Kozuma,Mika Saito,Hirofumi Zempo,Shingo Matsumoto,Naoyuki Kobatake,Koichi Nakazato,Takanobu Okamoto,George John,Rinat A Yusupov,Andrey K Larin,Nikolay A Kulemin,Ilnaz M Gazizov,Edward V Generozov,Ildus I Ahmetov
- 担当区分
- 概要
- 概要（英）
- The greater muscle fiber cross-sectional area (CSA) is associated with greater skeletal muscle mass and strength, whereas muscle fiber atrophy is considered a major feature of sarcopenia. Muscle fiber size is a polygenic trait influenced by both environmental and genetic factors. However, the genetic variants underlying inter-individual differences in muscle fiber size remain largely unknown. The aim of our study was to determine whether 1535 genetic variants previously identified in a genome-wide association study of appendicular lean mass are associated with the CSA of fast-twitch muscle fibers (which better predict muscle strength) in the m. vastus lateralis of 148 physically active individuals (19 power-trained and 28 endurance-trained females, age 28.0 ± 1.1; 28 power-trained and 73 endurance-trained males, age 31.1 ± 0.8). Fifty-seven single-nucleotide polymorphisms (SNPs) were identified as having an association with muscle fiber size (p < 0.05). Of these 57 SNPs, 31 variants were also associated with handgrip strength in the UK Biobank cohort (n = 359,729). Furthermore, using East Asian and East European athletic (n = 731) and non-athletic (n = 515) cohorts, we identified 16 SNPs associated with athlete statuses (sprinter, wrestler, strength, and speed-strength athlete) and weightlifting performance. All SNPs had the same direction of association, i.e., the lean mass-increasing allele was positively associated with the CSA of muscle fibers, handgrip strength, weightlifting performance, and power athlete status. In conclusion, we identified 57 genetic variants associated with both appendicular lean mass and fast-twitch muscle fiber size of m. vastus lateralis that may, in part, contribute to a greater predisposition to power sports.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- Cells
- 巻
- 13
- 号
- 14
- 開始ページ
- 終了ページ
- 出版年月
- 2024年7月18日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3390/cells13141212
- 共同研究・競争的資金等の研究課題