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最終更新日：2024/04/22
下山 寛之
サガヤマ ヒロユキ
(Hiroyuki Sagayama)
論文
- タイトル
- Urinary N-terminal fragment of titin: A surrogate marker of serum creatine kinase activity after exercise-induced severe muscle damage
- タイトル（英）
- Urinary N-terminal fragment of titin: A surrogate marker of serum creatine kinase activity after exercise-induced severe muscle damage
- 参照URL
- https://researchmap.jp/gs070100/published_papers/31984570
- 著者
- Tanabe, Yoko,Shimizu, Kazuhiro,Sagayama, Hiroyuki,Fujii, Naoto,Takahashi, Hideyuki
- 著者（英）
- Tanabe, Yoko,Shimizu, Kazuhiro,Sagayama, Hiroyuki,Fujii, Naoto,Takahashi, Hideyuki
- 担当区分
- 概要
- We aimed to evaluate whether changes in the noninvasively assessed urinary N-terminal fragment of titin (U-titin) concentration may be associated with those of serum creatine kinase (CK) activity, transverse relaxation time (T), maximal voluntary contraction (MVC) torque, range of motion (ROM), and muscle soreness, following high-intensity eccentric exercise. Twenty-eight healthy young men performed 30 maximal isokinetic (120°/s) eccentric elbow flexor contractions using an isokinetic dynamometer. U-titin concentration, serum CK activity, T, MVC torque, ROM, and muscle soreness were measured before and after a maximum of 4 days. Both U-titin concentration and serum CK activity increased post-exercise in a similar manner, though the former elevated slightly earlier (p < 0.05). The peak values of log U-titin concentration following eccentric exercise were strongly correlated with those of log serum CK activity (r = 0.90, p < 0.05) and T (r = 0.84, p < 0.05). There were moderate correlations between peak values of U-titin concentration and those of MVC torque (r = 0.69, p < 0.05) and ROM decline rate (r = 0.45, p < 0.05). These results suggest that in healthy young men
- 概要（英）
- We aimed to evaluate whether changes in the noninvasively assessed urinary N-terminal fragment of titin (U-titin) concentration may be associated with those of serum creatine kinase (CK) activity, transverse relaxation time (T), maximal voluntary contraction (MVC) torque, range of motion (ROM), and muscle soreness, following high-intensity eccentric exercise. Twenty-eight healthy young men performed 30 maximal isokinetic (120°/s) eccentric elbow flexor contractions using an isokinetic dynamometer. U-titin concentration, serum CK activity, T, MVC torque, ROM, and muscle soreness were measured before and after a maximum of 4 days. Both U-titin concentration and serum CK activity increased post-exercise in a similar manner, though the former elevated slightly earlier (p < 0.05). The peak values of log U-titin concentration following eccentric exercise were strongly correlated with those of log serum CK activity (r = 0.90, p < 0.05) and T (r = 0.84, p < 0.05). There were moderate correlations between peak values of U-titin concentration and those of MVC torque (r = 0.69, p < 0.05) and ROM decline rate (r = 0.45, p < 0.05). These results suggest that in healthy young men
- 出版者・発行元
- TAYLOR & FRANCIS LTD
- 出版者・発行元（英）
- TAYLOR & FRANCIS LTD
- 誌名
- Journal of sports sciences
- 誌名（英）
- Journal of sports sciences
- 巻
- 39
- 号
- 13
- 開始ページ
- 1437
- 終了ページ
- 1444
- 出版年月
- 2021年3月
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- 1466-447X
- DOI URL
- https://doi.org/10.1080/02640414.2021.1876329
- 共同研究・競争的資金等の研究課題