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最終更新日：2024/11/08
清水 和弘
シミズ カズヒロ
(Kazuhiro Shimizu)
論文
- タイトル
- タイトル（英）
- Acute salivary antimicrobial peptide secretion response to different exercise intensities and durations.
- 参照URL
- https://researchmap.jp/read0128841/published_papers/47729195
- 著者
- 著者（英）
- Reita Ito,Takamasa Uchino,Masataka Uchida,Shumpei Fujie,Keiko Iemitsu,Chihiro Kojima,Mariko Nakamura,Kazuhiro Shimizu,Yuko Tanimura,Yasushi Shinohara,Takeshi Hashimoto,Tadao Isaka,Motoyuki Iemitsu
- 担当区分
- 概要
- 概要（英）
- Antimicrobial peptides, key players of innate mucosal immunity in the oral cavity, exert antibacterial and bacteriolytic effects. This study aimed to clarify the effects of acute exercise at different intensities and durations on salivary antimicrobial peptide levels. In a randomized crossover trial, 14 young healthy untrained men performed intensity trials (cycling at 35%, 55%, and 75% of maximal oxygen uptake [VO2max] for 30 min) and duration trials (cycling at 55% VO2max for 30, 60, and 90 min). Saliva samples were collected at baseline and 0 and 60 min after exercise. In intensity trials, the change in salivary Lactoferrin levels from baseline to 0 min after 30-min exercise was greater at 75% VO2max exercise intensity compared to that at 35% VO2max. Furthermore, the change in salivary human beta defensin-2 (HBD-2) levels was greater at 75% VO2max compared to that at 35% and 55% VO2max. Salivary Lysozyme levels increased after exercise, independent of exercise intensity. However, salivary LL-37 levels did not change after exercise at any intensity. Additionally, in duration trials, the change in salivary levels of LL-37 and HBD-2 from baseline to 0 min after exercise at 55% VO2max was greater after 60 min and 90 min of exercise compared to that after 30 min of exercise. However, salivary Lactoferrin and Lysozyme levels increased after exercise, independent of exercise duration. Our findings suggest that secretory responses to acute exercise with exercise intensity and duration differ among salivary antimicrobial peptides.
- 出版者・発行元
- 出版者・発行元（英）
- 誌名
- 誌名（英）
- American journal of physiology. Regulatory, integrative and comparative physiology
- 巻
- 号
- 開始ページ
- 終了ページ
- 出版年月
- 2024年8月19日
- 査読の有無
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.1152/ajpregu.00132.2024
- 共同研究・競争的資金等の研究課題