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最終更新日：2024/04/26

田中喜晃

タナカヨシアキ (Yoshiaki Tanaka)

論文

タイトル
タイトル（英）: Effects of eicosapentaenoic acid on serum levels of selenoprotein P and organ‐specific insulin sensitivity in humans with dyslipidemia and type 2 diabetes
参照URL: https://researchmap.jp/yoshiaki-tanaka/published_papers/46302106
著者
著者（英）: Yumie Takeshita,Chisato Teramura,Kyoko Kamoshita,Hiroaki Takayama,Hiromi Nakagawa,YASUFUMI ENYAMA,Kiyo‐Aki Ishii,Takeo Tanaka,Hisanori Goto,Yujiro Nakano,Sachie Osada,Yoshiaki Tanaka,Kumpei Tokuyama,Toshinari Takamura
担当区分
概要
概要（英）: ABSTRACTAimSelenoprotein P (SeP, encoded by SELENOP in humans) is a hepatokine that causes insulin resistance in the liver and skeletal muscle. It was found that polyunsaturated fatty acid eicosapentaenoic acid (EPA) downregulates Selenop expression by inactivating SREBP‐1c. The present study aimed to examine the effect of EPA for 12 weeks on circulating SeP levels and insulin sensitivity in humans with type 2 diabetes.MethodsA total of 20 participants with dyslipidemia and type 2 diabetes were randomly assigned to an EPA (900 mg, twice daily) group and a control group. The primary endpoint was a change in serum SeP levels. Organ‐specific insulin sensitivity in the liver (HGP and %HGP), skeletal muscle (Rd), and adipose tissue (FFA and %FFA) were assessed using a hyperinsulinemic‐euglycemic clamp study with stable isotope‐labeled glucose infusion.ResultsSerum SeP levels were not changed in either group at the end of the study. In the EPA group, the changes in SeP levels were positively correlated with the change in serum EPA levels (r = 0.709, P = 0.022). Treatment with EPA significantly enhanced %FFA but not %HGP and Rd. The change in serum EPA levels was significantly positively correlated with the change in %HGP, and negatively correlated with changes in Rd.ConclusionsThe change in serum EPA levels was positively correlated with serum SeP levels, hepatic insulin sensitivity, and negatively with skeletal muscle insulin sensitivity in humans with type 2 diabetes. The EPA‐induced enhancement of hepatic insulin sensitivity might be associated with a mechanism independent of serum SeP levels.
出版者・発行元
出版者・発行元（英）
誌名
誌名（英）: Journal of Diabetes Investigation
巻
号
開始ページ
終了ページ
出版年月: 2022年3月
査読の有無
招待の有無
掲載種別: 研究論文（学術雑誌）
ISSN: 2040-1116,2040-1124
DOI URL: https://doi.org/10.1111/jdi.13699
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田中 喜晃

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田中喜晃