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最終更新日:2024/02/01

大岩 奈青

オオイワ ナオ (Nao Ohiwa)
MISC
タイトル
タイトル(英)
Athlome project consortium: A concerted effort to discover genomic and other "omic" markers of athletic performance
参照URL
https://researchmap.jp/naoohiwa/misc/31761906
著者
著者(英)
Yannis P. Pitsiladis,Masashi Tanaka,Nir Eynon,Claude Bouchard,Kathryn N. North,Alun G. Williams,Malcolm Collins,Colin N. Moran,Steven L. Britton,Noriyuki Fuku,Euan A. Ashley,Vassilis Klissouras,Alejandro Lucia,Ildus I. Ahmetov,Eco De Geus,Mohammed Alsayrafi,Nick Webborn,Guan Wang,David J. Bishop,Ioannis Papadimitriou,Xu Yan,Oren Tirosh,Jujiao Kuang,Tuomo Rankinen,Mark Sarzinsky,C. Mikael Mattsson,Matthew Wheeler,Daryl Waggott,Nuala M. Byrne,Guilherme G. Artioli,Alison September,Michael Posthumus,Willem Van der Merwe,Pawel Cieszczyk,Agata Leonska-Duniec,Krzysztof Ficek,Agnieszka Maciejewska-Karlowska,Marek Sawczuk,Marta Stepien-Slodkowska,Julian Feller,Paul Dijkstra,Aleksandr M. Chmutov,Dmitry A. Dyatlov,Evgeniy F. Orekhov,Yuliya E. Pushkareva,Irina A. Shvedkaya,Myosotis Massidda,Carla M. Calò,Stephen H. Day,Georgina K. Stebbings,Robert M. Erskine,Hugh E. Montgomery,Fleur C. Garton,Peter Houweling,Wim Derave,Audrey Baguet,Carlos A. Muniesa,Francesco Sessa,Annamarie Petito,Craig Sale,David C. Hughes,Ian Varley,Dorret Boomsma,Meike Bartels,Gareth E. Davies,Valentina Ginevičienė,Audronė Jakaitienė,Vaidutis Kučinskas,Linas Tubelis,Algirdas Utkus,Kazys Milašius,Tomas Venckunas,Albertas Skurvydas,Arvydas Stasiulis,Dalia Malkova,Richard Wilson,Lauren G. Koch,Hirofumi Zempo,Hisashi Naito,Naoki Kikuchi,Eri Miyamoto-Mikami,Haruka Murakami,Motohiko Miyachi,Hideyuki Takahashi,Nao Ohiwa,Takashi Kawahara,Hiroyasu Tsuchie,Takuro Tobina,Noriko Ichinoseki-Sekine,Hiroaki Tanaka,Koji Kaneoka,Koichi Nakazato,Emiliya S. Egorova,Leysan J. Gabdrakhmanova,Alina A. Arkhipova,Alyona V. Borisova,Rashid T. Gabbasov,Albina A. Stepanova,Ravil I. Kashapov,Victor A. Rogozkin
担当区分
概要
概要(英)
© 2016 the American Physiological Society. Despite numerous attempts to discover genetic variants associated with elite athletic performance, injury predisposition, and elite/world-class athletic status, there has been limited progress to date. Past reliance on candidate gene studies predominantly focusing on genotyping a limited number of single nucleotide polymorphisms or the insertion/deletion variants in small, often heterogeneous cohorts (i.e., made up of athletes of quite different sport specialties) have not generated the kind of results that could offer solid opportunities to bridge the gap between basic research in exercise sciences and deliverables in biomedicine. A retrospective view of genetic association studies with complex disease traits indicates that transition to hypothesis-free genome-wide approaches will be more fruitful. In studies of complex disease, it is well recognized that the magnitude of genetic association is often smaller than initially anticipated, and, as such, large sample sizes are required to identify the gene effects robustly. A symposium was held in Athens and on the Greek island of Santorini from 14 -17 May 2015 to review the main findings in exercise genetics and genomics and to explore promising trends and possibilities. The symposium also offered a forum for the development of a position stand (the Santorini Declaration). Among the participants, many were involved in ongoing collaborative studies (e.g., ELITE, GAMES, Gene SMART, GENESIS, and POWERGENE). A consensus emerged among participants that it would be advantageous to bring together all current studies and those recently launched into one new large collaborative initiative, which was subsequently named the Athlome Project Consortium.
出版者・発行元
出版者・発行元(英)
誌名
誌名(英)
Physiological Genomics
48
3
開始ページ
183
終了ページ
190
出版年月
2016年3月1日
査読の有無
招待の有無
掲載種別
書評論文,書評,文献紹介等
ISSN
1094-8341
DOI URL
https://doi.org/10.1152/physiolgenomics.00105.2015
共同研究・競争的資金等の研究課題