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最終更新日:2024/04/01
安田 純
ヤスダ ジュン
(Jun Yasuda)
論文
- タイトル
- タイトル(英)
- Association of serum brain-derived neurotrophic factor with hepatic enzymes, AST/ALT ratio, and FIB-4 index in middle-aged and older women
- 参照URL
- https://researchmap.jp/junken/published_papers/39760359
- 著者
- 著者(英)
- Takumi Yokokawa,Shohei Sasaki,Kohei Sase,Naomi Yoshii,Jun Yasuda,Tatsuya Hayashi,Satoshi Fujita
- 担当区分
- 概要
- 概要(英)
- Substantial evidence suggests an important role of liver function in brain health. Liver function is clinically assessed by measuring the activity of hepatic enzymes in the peripheral blood. Brain-derived neurotrophic factor (BDNF) is an important regulator of brain function. Therefore, we hypothesized that blood BDNF levels are associated with liver function and fibrosis. To test this hypothesis, in this cross-sectional study, we investigated whether serum BDNF concentration is associated with liver enzyme activity, aspartate aminotransferase (AST)/ alanine aminotransferase (ALT) ratio, and fibrosis-4 (FIB-4) index in middle-aged and older women. We found that serum BDNF level showed a significant positive association with ALT and γ-glutamyltranspeptidase (GGT) activity and negative association with FIB-4 index, and a trend of negative association with the AST/ALT ratio after adjustment for age. Additionally, these associations remained statistically significant even after adjustment for body mass index (BMI) and fasting blood glucose level. These results demonstrate associations of serum BDNF levels with liver enzymes and hepatic fibrosis-related indices, which may underlie liver-brain interactions.
- 出版者・発行元
- 出版者・発行元(英)
- Public Library of Science (PLoS)
- 誌名
- 誌名(英)
- PLOS ONE
- 巻
- 17
- 号
- 8
- 開始ページ
- e0273056
- 終了ページ
- e0273056
- 出版年月
- 2022年8月23日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文(学術雑誌)
- ISSN
- DOI URL
- https://doi.org/10.1371/journal.pone.0273056
- 共同研究・競争的資金等の研究課題