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最終更新日：2024/04/01
安田 純
ヤスダ ジュン
(Jun Yasuda)
論文
- タイトル
- タイトル（英）
- The Effect of Leucine-Enriched Essential Amino Acid Supplementation on Anabolic and Catabolic Signaling in Human Skeletal Muscle after Acute Resistance Exercise: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Trial
- 参照URL
- https://researchmap.jp/junken/published_papers/29416856
- 著者
- 著者（英）
- Junya Takegaki,Kohei Sase,Jun Yasuda,Daichi Shindo,Hiroyuki Kato,Sakiko Toyoda,Toshiyuki Yamada,Yasushi Shinohara,Satoshi Fujita
- 担当区分
- 概要
- 概要（英）
- Resistance exercise transiently activates anabolic and catabolic systems in skeletal muscle. Leucine-enriched essential amino acids (LEAAs) are reported to stimulate the muscle anabolic response at a lower dose than whey protein. However, little is known regarding the effect of LEAA supplementation on the resistance exercise-induced responses of the anabolic and catabolic systems. Here, we conducted a randomized, double-blind, placebo-controlled, parallel-group comparison trial to investigate the effect of LEAA supplementation on mechanistic target of rapamycin complex 1 (mTORC1), the ubiquitin–proteasome system and inflammatory cytokines after a single bout of resistance exercise in young men. A total of 20 healthy young male subjects were supplemented with either 5 g of LEAA or placebo, and then they performed 10 reps in three sets of leg extensions and leg curls (70% one-repetition maximum). LEAA supplementation augmented the phosphorylation of mTORSer2448 (+77.1%, p < 0.05), p70S6KThr389 (+1067.4%, p < 0.05), rpS6Ser240/244 (+171.3%, p < 0.05) and 4EBP1Thr37/46 (+33.4%, p < 0.05) after resistance exercise. However, LEAA supplementation did not change the response of the ubiquitinated proteins, MuRF-1 and Atrogin-1 expression. Additionally, the mRNA expression of IL-1β and IL-6 did not change. These data indicated that LEAA supplementation augments the effect of resistance exercise by enhancing mTORC1 signal activation after exercise.
- 出版者・発行元
- 出版者・発行元（英）
- {MDPI} {AG}
- 誌名
- 誌名（英）
- Nutrients
- 巻
- 12
- 号
- 8
- 開始ページ
- 2421
- 終了ページ
- 2421
- 出版年月
- 2020年8月12日
- 査読の有無
- 査読有り
- 招待の有無
- 掲載種別
- 研究論文（学術雑誌）
- ISSN
- DOI URL
- https://doi.org/10.3390/nu12082421
- 共同研究・競争的資金等の研究課題