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最終更新日：2024/04/19

清水和弘

シミズカズヒロ (Kazuhiro Shimizu)

論文

タイトル
タイトル（英）: Urinary N-terminal fragment of titin: A surrogate marker of serum creatine kinase activity after exercise-induced severe muscle damage.
参照URL: https://researchmap.jp/read0128841/published_papers/31854274
著者
著者（英）: Yoko Tanabe,Kazuhiro Shimizu,Hiroyuki Sagayama,Naoto Fujii,Hideyuki Takahashi
担当区分
概要
概要（英）: We aimed to evaluate whether changes in the noninvasively assessed urinary N-terminal fragment of titin (U-titin) concentration may be associated with those of serum creatine kinase (CK) activity, transverse relaxation time (T2), maximal voluntary contraction (MVC) torque, range of motion (ROM), and muscle soreness, following high-intensity eccentric exercise. Twenty-eight healthy young men performed 30 maximal isokinetic (120°/s) eccentric elbow flexor contractions using an isokinetic dynamometer. U-titin concentration, serum CK activity, T2, MVC torque, ROM, and muscle soreness were measured before and after a maximum of 4 days. Both U-titin concentration and serum CK activity increased post-exercise in a similar manner, though the former elevated slightly earlier (p < 0.05). The peak values of log U-titin concentration following eccentric exercise were strongly correlated with those of log serum CK activity (r = 0.90, p < 0.05) and T2 (r = 0.84, p < 0.05). There were moderate correlations between peak values of U-titin concentration and those of MVC torque (r = 0.69, p < 0.05) and ROM decline rate (r = 0.45, p < 0.05). These results suggest that in healthy young men, the non-invasive marker, U-titin, may be used as a serum CK surrogate following exercise-induced severe muscle damage.
出版者・発行元
出版者・発行元（英）
誌名
誌名（英）: Journal of Sports Sciences
巻
号
開始ページ: 1
終了ページ: 8
出版年月: 2021年3月16日
査読の有無: 査読有り
招待の有無
掲載種別: 研究論文（学術雑誌）
ISSN
DOI URL: https://doi.org/10.1080/02640414.2021.1876329
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